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Abstract #0440

Investigation of Skeletal Muscle Lipid Composition by Localized Correlated Spectroscopy with Weight Loss Intervention: Preliminary Results

Suresh Anand Sadananthan1, 2, Eric Khoo Yin Hao3, Melvin K-S Leow1, 4, ChinMeng Khoo3, Lee Yung Seng1, 5, Peter Gluckman1, Tai E Shyong1, 3, S. Sendhil Velan1, 6

1Singapore Institute for Clinical Sciences, A*STAR, Singapore; 2Dept. of Obstetrics & Gynaecology, National University of Singapore, Singapore; 3Dept. of Medicine, National University of Singapore; 4Dept. of Endocrinology, Tan Tock Seng Hospital; 5Dept. of Pediatrics, National University of Singapore; 6Singapore Bioimaging Consortium, A*STAR, Singapore

Fatty acid composition in individuals with insulin resistance and metabolic syndrome is typically characterized by high levels of saturated fatty acids and low levels of polyunsaturated fatty acids. Recently, the degree of IMCL unsaturation was shown to significantly decrease with BMI in overweight and obese Caucasian men. However, the saturated and unsaturated components within these lipid pools have not been thoroughly investigated after a weight loss intervention. In this study, we employed a 2D localized correlated spectroscopy (L-COSY) technique to estimate the degree of unsaturation within IMCL and EMCL in overweight Chinese subjects after a weight loss intervention.