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Abstract #0469

Voxel-Wise Estimation of M & CMRO2 at 7T

MAGNA25Emma Louise Hall1, Ian D. Driver1, Susan E. Pritchard1, Penny A. Gowland1, Susan T. Francis1

1Sir Peter Mansfield MR Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

The Davis model is widely used to estimate the change in CMRO2 in response to a stimulus. This requires the measurement of CBF and BOLD in response to a stimulus and hypercapnia. Increased sensitivity at 7T allows voxelwise assessment of CBF and BOLD, and multiphase ASL allows transit time independent estimation of CBF. Here we estimate M and CMRO2 for a motor task on a voxel-by-voxel basis compared to standard ROI analysis, for a CBF and BOLD ROI. A BOLD based ROI leads to overestimation of M and reduction in CMRO2 compared to voxelwise analysis, and a CBF based ROI.