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Abstract #0488

Comparison of Cerebral Glutamate & GABA in Schizotypal Personality Disorder Using Spectral Editing & 2D Correlated Spectroscopy

Alexander Peter Lin1, Huijun Liao2, Ana Cadena2, Saadallah Ramadan3, Israel Molina4, Robert McCarley5

1Center for Clinical Spectroscopy , Brigham and Women's Hospital , Boston, MA, United States; 2Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States; 3School of Health Sciences, University of Newcastle, Callaghan , New South Wales, Australia; 4Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton, MA, United States; 5Psychiatry at Veterans Affairs Boston Healthcare System, Harvard Medical School, Brockton, MA, United States

Schizotypal personality disorder shares biological, genetic, and clinical features of schizophrenia however little is known the alterations of brain neurochemistry, in particular the important neurotransmitters of GABA and glutamate. Our goal was to use spectral editing and 2D correlated spectroscopy techniques to measure the concentration of these chemicals in SPD subjects. Our results show a decrease in GABA and increase in glutamate in SPD subjects when compared with controls. Results of the different MRS methods were also compared and showed to share the same results however 2D COSY provided additional information beyond the other techniques.