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Abstract #0491

Multimodal Validation of Oxidative Stress as a Pathophysiological Model of Chronic Fatigue Syndrome

Dikoma C. Shungu1, Nora Weiduscat1, James W. Murrough2, Xiangling Mao1, Sarah Pillemer2, Marvin S. Meddow3, Jonathan P. Dyke1, Benjamin H. Natelson4, Julian M. Stewart3, Sanjay J. Mathew5

1Radiology, Weill Cornell Medical College, New York, United States; 2Psychiatry, Mount Sinai School of Medicine; 3New York Medical College; 4Beth Israel Medical Center; 5Baylor College of Medicine

This study used multiple MR methods, including MRS measurement of the major antioxidant glutathione (GSH), to test the hypothesis that oxidative stress plays a major role in the pathophysiology of chronic fatigue syndrome (CFS).