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Abstract #0499

Peri-Lesional White Matter Changes in Clinically Isolated Syndrome Suggestive of Demyelination on MTR & MPRAGE at 7T

SUMMA25Anna Blazejewska1, Ali Al-Radaideh2, Olivier Mougin2, Su Yin Lin3, Richard W. Bowtell2, Cris S. Constantinescu3, Penny A. Gowland2

1Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham; 3Department of Neurology, Clinical Sciences, University of Nottingham

A new method of characterizing peri-lesional changes in multiple sclerosis has been developed and tested on MTR and MPRAGE images from patients with Clinically Isolated Syndrome. It showed that all lesions display a proximal rim which is wider on MTR and MTRc than on T1w scans. More distally, most lesions show increases in MTR or T1w signal (negative S), but a significant fraction show a decrease (positive S) which indicates the presence of a ring around the lesion.