Abstract #0499

Peri-Lesional White Matter Changes in Clinically Isolated Syndrome Suggestive of Demyelination on MTR & MPRAGE at 7T

Anna Blazejewska¹, Ali Al-Radaideh², Olivier Mougin², Su Yin Lin³, Richard W. Bowtell², Cris S. Constantinescu³, Penny A. Gowland²

¹Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; ²Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham; ³Department of Neurology, Clinical Sciences, University of Nottingham

A new method of characterizing peri-lesional changes in multiple sclerosis has been developed and tested on MTR and MPRAGE images from patients with Clinically Isolated Syndrome. It showed that all lesions display a proximal rim which is wider on MTR and MTRc than on T1w scans. More distally, most lesions show increases in MTR or T1w signal (negative S), but a significant fraction show a decrease (positive S) which indicates the presence of a ring around the lesion.