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Abstract #0501

Anatomical Connectivity Mapping Measuring Connectivity Changes in Multiple Sclerosis

M. Lyksborg1, 2, R. Larsen1, P. S. Srensen3, M. Blinkenberg3, A. Dogonowski2, E. Garde2, G. J.M. Parker4, H. R. Siebner2, T. B. Dyrby2

1Technical University Of Denmark, Kgs. Lyngby, Denmark; 2Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark; 3Danish Multiple Sclerosis Research Center, Denmark; 4University Of Manchester, United Kingdom

Multiple sclerosis is a disease with a highly heterogeneous disease pattern where lesions along a given tract may have varying impact on the global anatomical connectivity of the underlying axons. In the following we demonstrate how the technique of Anatomical Connectivity Mapping is capable of quantifying anatomical connectivity differences between two patient groups with High/low EDSS disease scores. Strong group differences are seen along corticospinal tract, in cerebellar white matter and subcortical white matter in the visual cortex. Results show that such differences are not distinguishable with traditional diffusion measures.