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Abstract #0579

Volumetric Measurement of Perfusion & Arterial Transit Delay Using Hadamard Encoded Continuous Arterial Spin Labeling

SUMMA25Weiying Dai1, Ajit Shankaranarayanan2, David Alsop1

1Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, United States

Hadamard encoded arterial spin labeling techniques have been proposed to increase the SNR and time efficiency of multiple delay methods for arterial transit delay (ATD) measurement. Here, we report methods for robust Hadamard encoded CASL with volumetric acquisition in humans. The SNR of the Hadamard encoded measurements of ATD and perfusion were compared to more standard acquisitions. Hadamard encoded ASL provided the most sensitive measure of ATD, but its sensitivity for perfusion was approximately half that of CASL acquisitions when ATD is known or assumed.