Abstract #0579

Volumetric Measurement of Perfusion & Arterial Transit Delay Using Hadamard Encoded Continuous Arterial Spin Labeling

Weiying Dai¹, Ajit Shankaranarayanan², David Alsop¹

¹Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States; ²Global Applied Science Laboratory, GE Healthcare, Menlo Park, United States

Hadamard encoded arterial spin labeling techniques have been proposed to increase the SNR and time efficiency of multiple delay methods for arterial transit delay (ATD) measurement. Here, we report methods for robust Hadamard encoded CASL with volumetric acquisition in humans. The SNR of the Hadamard encoded measurements of ATD and perfusion were compared to more standard acquisitions. Hadamard encoded ASL provided the most sensitive measure of ATD, but its sensitivity for perfusion was approximately half that of CASL acquisitions when ATD is known or assumed.