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Abstract #0589

Voxel-Based Relaxometry in Parkinson Variant of Multiple System Atrophy: A Pilot R2* Study on 3T and Comparison with Voxel-Based Morphometry

Bo Hou1, Han Wang2, Hui You1, Feng Feng1

1Department of radiology, Peking Union Medical College Hospital, Beijing, China; 2Department of Neurology, Peking Union Medical College Hospital, Beijing, China

Relaxation rate is thought to be a sensitive marker to reflect regional degeneration prior to morphological changes, while the available voxel-based relaxometry(VBR) studies on Parkinsonian variant of multiple system atrophy(MSA-P) did not reveal the distribution of abnormal relaxation as voxel-based morphometry (VBM).This study tries to explore this issue with a 3T scanner and a multi-echo GRE sequence. The objective voxel-based method was used for statistical analysis. The result of VBR comparing MSA-P and control matches well with the VBM results, and also revealed corpus callosum involvement which is spared in VBM, confirming a good availability of this method.