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Abstract #0646

Globally Impaired Network of Anatomical Connectivity in Tuberous Sclerosis Complex Patients with Autism Spectrum Disorders

MAGNA25Benoit Scherrer1, Mustafa Sahin1, Caterina Stamoulis1, Sanjay P. Prabhu1, Alireza Akhondi-Asl1, Simon K. Warfield1

1Radiology, Harvard Medical School, Children Hospital Boston, Boston, MA, United States

This study is to our knowledge the first to investigate with diffusion imaging the network of anatomical connectivity in tuberous sclerosis complex (TSC) patients and its relationship to autism spectrum disorder (ASD). Our results suggest that the network is globally significantly affected in TSC patients with ASD.