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Abstract #0653

Strong Correlation between Hippocampal Volume & Integrity of Inferior Cingulum Bundle in Patients with Mesial Temporal Lobe Epilepsy

Y.C. Shih1, 2, C. E. J. Tseng3, H.H. Liou4, P.Y. Chen2, F.H. Lin1, W.Y. I. Tseng2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan Univerity College of Medicine, Taipei, Taiwan, Taiwan; 3Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 4Department of Neurology, National Taiwan University Hospital, Taiwan

Hippocampal sclerosis (HS) is the common abnormality observed in patients with mesial temporal lobe epilepsy (MTLE). MTLE affects the networks of regions that are anatomically connected to the hippocampus. Since the hippocampus is a terminal node of the inferior cingulum bundles (CB), we hypothesized that the integrity of the inferior CB is related to the atrophy of the hippocampus. In this study, we evaluated the integrity of white matter by diffusion spectrum imaging (DSI) and the atrophy of hippocampus by the volume measurement, and investigated their relationship.