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Abstract #0657

GABA Concentration Predicts the Strength of Functional Connectivity

Xi Chen*1, Hong Gu*1, Yihong Yang1

1Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States

We have found negative correlation between the GABA concentration and correlation strength of BOLD signals at rest in primary visual cortex in this study and both of these resting neurotransmitter and hemodynamic indices predict the amplitude of evoked BOLD responses to visual stimuli. A mediation analysis shows that functional connectivity strength acts as a mediator in the relationship of the GABA concentration vesus task activation prediction.