Abstract #0664

Noninvasive Estimation of Pulmonary Vascular Resistance with 4D Flow-Sensitive MRI in a Canine Model of Acute Pulmonary Arterial Hypertension

Alejandro Roldan-Alzate¹, Alex Frydrychowicz², Leif Jensen¹, Scott K. Nagle¹, Heidi Kellihan³, Naomi Chesler⁴, Oliver Wieben¹,⁵, Christopher J. Franois¹

¹Radiology, University of Wisconsin, Madison, WI, United States; ²Radiology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany; ³Veterinary Medicine, University of Wisconsin, Madison, WI, United States; ⁴Biomedical Engineering, University of Wisconsin, Madison, WI, United States; ⁵Medical Physics, University of Wisconsin, Madison, WI, United States

Pulmonary vascular resistance (PVR) is a hemodynamic parameter that is used to assess disease severity and to guide the management of patients with a variety of cardiovascular and pulmonary conditions. 4D flow-sensitive MRI is increasingly being used for hemodynamic analyses of cardiovascular diseases, including pulmonary arterial hypertension. PC VIPR is a time-efficient 4D flow-sensitive MRI technique, using radial undersampling, to obtain high spatial resolution data with a large volume of coverage. In this study we validated the use of PC VIPR data for the estimation of PVR in a canine model of acute pulmonary arterial hypertension.