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Abstract #0676

Imaging Tumor Colonization with an Oncolytic Vaccinia Virus Strain (GLV-1h68) in a Melanoma Model by 19F MRI

SUMMA25Thomas Christian Basse-Lsebrink1, 2, Stephanie Weibel2, Elisabeth Hofmann2, Johanna Langbein2, Volker Jrg Friedrich Sturm1, Thomas Kampf1, Peter Michael Jakob1, Aladr Szalay2, 3

1Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Biochemistry, University of Wrzburg, Wrzburg, Bavaria, Germany; 3Genelux Corporation, San Diego, CA, United States

In recent years, it was shown that oncolytic virus strains such as attenuated vaccinia virus have a promising therapeutic potential in the treatment of cancer. Importantly, the infection of tumors with viral agents often induces massive inflammation within the tumor microenvironment. In the past, 19F markers have shown their potential for visualizing inflammation in vivo using 19F MRI. Thus, the purpose of the present study was to monitor in vivo inflammation by employing 19F 3D MRI in a vaccinia virus treated melanoma model and to compare the spatial 19F patterns to non-infected controls. Furthermore, ex vivo 19F MRI and immunohistochemistry were performed to verify in vivo results.