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Abstract #0713

Optimized Diffusion-Weighted LASER Sequence for Single-Shot Measurement of Metabolite Diffusion by the Trace of the Tensor

SUMMA25Charlotte Marchadour1, 2, Vincent Lebon1, 2, Julien Valette1, 2

1CEA-MIRCen, Fontenay-aux-Roses, France; 2CEA-CNRS URA 2210, Fontenay-aux-Roses, France

One way to characterize intracellular microenvironment regardless of anisotropic organization is the measurement of the trace of the diffusion tensor (Dav) for intracellular metabolites by diffusion-weighted spectroscopy. Here we propose a sequence to measure Dav in a single scan. This sequence consists in two improvements of a previously proposed sequence. First, diffusion gradients are inserted to fill the whole dead time of the sequence. Second, effective gradient amplitude is increased by combining gradients to generate a new set of three orthogonal directions. These two modifications yield a significant 2.75 increase of the b-value while keeping echo time unchanged.