Nadia Benkhedah1, Peter Bachert1, Wolfhard Semmler1, Armin M. Nagel1
1Dept. of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Triple-quantum filtered (TQF) sodium images were proposed to image intracellular sodium ions. However, TQF images suffer from signal to noise ratios (SNR) an order of magnitude lower than normal sodium images. TQF image contrast can be generated by the difference of a tissue sodium concentration weighted image and a single-quantum filtered image acquired in one measurement. The developed method is evaluated on both, phantom and in vivo data. Images generated with this new difference image method show significantly higher SNR and seem to be less sensitive to main magnetic field inhomogeneities.