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Abstract #0734

Evidence of Reduced Cardiac Calcium Channel Activity & the Reversal of Sodium-Calcium Exchanger in Ischemia/Reperfusion Injury by Manganese-Enhanced MRI

Ya Chen1, Akemichi Baba2, Toshio Matsuda2, Xin Yu1

1Department of Biomedical Engineering and Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States; 2Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

The present study aimed at investigating whether manganese-enhanced MRI (MEMRI) is also sensitive to detect the calcium channel and NCX activities after ischemia during earlier reperfusion. Using a rapid T1-mapping method, we investigated the dynamics of R1 changes in manganese-perfused rat hearts with and without 20 min ischemia and with and without NCX inhibition by SEA0400.