Samuel James Wharton1, Richard Bowtell1
1Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
Recent work has shown that magnitude images acquired using gradient echo (GE) techniques at high field are sensitive to the fiber-orientation in white matter. Here, we show that frequency difference mapping (FDM) based on acquisition of multi-echo GE data allows the strong fiber-orientation contrast in phase images to be exploited in producing high resolution, 3D fiber-orientation maps. This approach was tested on post-mortem brain samples by comparing the resulting orientation maps to DTI data and fiber-orientation maps generated from simultaneously acquired R2* maps. The results suggest that FDM at high field may be used for high resolution fiber-orientation mapping.