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Abstract #0767

Multi-Parametric Quantitative Magnetic Resonance Imaging of the Normal Appearing Brain in Multiple Sclerosis

JBM Warntjes1, 2, I Blystad3, A Tisell1, 4, AM Landtblom5, P Lundberg1, 6

1Center for Medical Image Science and Visualization, Linkping, Sweden; 2Department of Medical and Health Sciences, Clinical Physiology, Linkping, Sweden; 3Department of Medical and Health Sciences, Radiology, Linkping, Sweden; 4Department of Medical and Health Sciences, Radiation Physics, Linkping, Sweden; 5Clinical Neuroscience, Linkping, Sweden; 6County Council of stergtland, Department of Radiology UHL, Linkping, Sweden

In this study a previously reported magnetic resonance quantification method was applied to 16 healthy subjects and 16 patients diagnosed with Multiple Sclerosis. The absolute R1 and R2 relaxation rates and the proton density PD were retrieved in 11 different regions of the brain, carefully avoiding the visible MS lesions or diffuse hyper-intense areas in the patient group. Although the variation of the measured values increased in the MS group no significant difference was observed for normal appearing matter compared to the normal, healthy brain, except for the peritrigonial white matter.