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Abstract #0774

The Impact of Maximum Turning Angle in Different Deterministic Tractography Algorithms Applied in Pediatric Populations

Katyucia de Macedo Rodrigues1, 2, Emma Ben-Avi2, P Ellen Grant, 23, Randy Gollub2, Paul Caruso4, Kalpathy Krishnamoorthy5, Lilla Zollei2

1Radiology, Childrens Hospital Boston, Boston, MA, United States; 2Radiology, Martinos Center/MGH, Boston, MA, United States; 3Center for Fetal-Neonatal Neuroimaging & Developmental Science, Children's Hospital Boston, Boston, MA, United States; 4Radiology, Massachusetts General Hospital, Boston, MA, United States; 5NEUROLOGY, Massachusetts General Hospital, Boston, MA, United States

Tractography analysis has been largely used to evaluate integrity of white matter, to locate specific tracts and to map connectivity. Different DWI acquisitions and post processing methods often make comparisons between studies challenging, with modification in a single parameter resulting in considerable changes in the final product. Because there is no consensus on how to post-process diffusion data, we sought to demonstrate the impact of maximum turning angle along tracts in four deterministic tractography reconstruction algorithms in pediatric population. Our results suggest optimal angle threshold may change when using different post-processing algorithms and may vary when analyzing different fiber bundles.