Alex M. Wong1, Feng-Xian Yan2, Ho-Ling Liu1, 2
1Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan
We compared the 3D FSE pseudo-continuous ASL (PCASL) perfusion method with gradient-gradient (GE) and spin-echo (SE) dynamic susceptibility contrast (DSC) MRI in a group of 12 patients. In each patient, ratios of mean CBF in the cortical gray matter (GM) to deep white matter (WM) were obtained for the comparison. The results showed significant positive correlations between measurements from PCASL and either of the two DSC methods (r=0.72 (GE), 0.81 (SE), p < 0.05). The SE-DSC resulted in similar GM/WM ratios as PCASL, whereas GE-DSC yielded overestimated ratios which may be attributed to its greater sensitivity to large vessels.
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