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Abstract #0799

Differential Pattern of Striatal Cerebral Blood Volume After a Haloperidol Challenge in Rats

Dirk Ernst Cleppien1, Alexander Sartorius2, Claudia Falfan-Melgoza1, Natalia Gass1, Lei Zheng3, Wolfgang Weber-Fahr1

1NeuroImaging, Central Institute of Mental Health, Mannheim, Germany; 2Clinic of Psychiatry and Psychotherapie, Central Institute of Mental Health, Mannheim, Germany; 3Experimental Radiation Oncology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany

Haloperidol is a widely used antipsychotic drug with potent dopamine D2 receptor antagonistic properties. To understand its impact on the striatum high-resolution regional cerebral blood volume (rCBV) mapping with magnetic resonance imaging was performed in 10 rats. The standardized rCBV maps show areas of activation corresponding well with the findings in the literature under c-fos activation. A deactivation in the central caudate-putamen could corroborate findings of a T2* signal loss in some parts of the CPu. This underlines the importance of high-resolution functional rCBV measurements covering larger parts of the brain.