Abstract #0823

Multi-Modal Post Mortem MRI at 7T to Detect and Quantify Multiple Sclerosis Cortical Grey Matter Pathology

Olivier E. Mougin¹, Niraj Mistry², Penny A. Gowland¹, Nikos Evangelou², Klaus Schmierer³

¹Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Select, United Kingdom; ²Institute of Neuroscience, Nottingham, Select, United Kingdom; ³Barts and The London School of Medicine & Dentistry, Blizard Institute, Centre for Neuroscience & Trauma (Neuroimmunology Group), London, United Kingdom

To explore their potential to detect cortical grey matter pathology we acquired T2 weighted (T2w), T2*w, double inversion recovery, phase-sensitive inversion recovery, and magnetization transfer ratio using fixed post mortem MS brain. Voxels of 0.35mm isotropic gave a clear delineation of the grey matter, both non-lesional and lesional. Our results suggest T2w and T2*w MRI are currently the best techniques to detect cortical grey matter lesions in post mortem MS brain.