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Abstract #0823

Multi-Modal Post Mortem MRI at 7T to Detect and Quantify Multiple Sclerosis Cortical Grey Matter Pathology

Olivier E. Mougin1, Niraj Mistry2, Penny A. Gowland1, Nikos Evangelou2, Klaus Schmierer3

1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Select, United Kingdom; 2Institute of Neuroscience, Nottingham, Select, United Kingdom; 3Barts and The London School of Medicine & Dentistry, Blizard Institute, Centre for Neuroscience & Trauma (Neuroimmunology Group), London, United Kingdom

To explore their potential to detect cortical grey matter pathology we acquired T2 weighted (T2w), T2*w, double inversion recovery, phase-sensitive inversion recovery, and magnetization transfer ratio using fixed post mortem MS brain. Voxels of 0.35mm isotropic gave a clear delineation of the grey matter, both non-lesional and lesional. Our results suggest T2w and T2*w MRI are currently the best techniques to detect cortical grey matter lesions in post mortem MS brain.