Abstract #0830

Strength of Connectivity to the Anterior Cingulate Predicts Processing Speed in Multiple Sclerosis

Katherine A. Koenig¹, Erik B. Beall¹, Jian Lin¹, Blessy Mathew¹, Lael Stone², Robert Bermel², Stephen Rao³, Bruce Trapp⁴, Micheal D. Phillips¹, Mark J. Lowe¹

¹Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; ²Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; ³Schey Center for Cognitive Neuroimaging, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; ⁴Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States

It has been shown that functional connectivity MRI (fcMRI) from the anterior cingulate (ACC) shows correlation with cognitive function in MS. In the current study, fcMRI from the ACC for 47 MS patients and 24 healthy controls was correlated with performance on the SDMT. In patients, SDMT performance was