Matthew Grech-Sollars1, Dawn E. Saunders2, Kim P. Phipps3, Jonathan D. Clayden1, Chris A. Clark1
1Imaging and Biophysics Unit, UCL Institute of Child Health, London, United Kingdom; 2Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom; 3Department of Neuro-oncology, Great Ormond Street Hospital for Children, London, United Kingdom
Apparent Diffusion Coefficient (ADC) measures have been shown to be related to tumour cellularity. We measured the gradient change in ADC values from the oedema into the tumour core (ATCT) in 58 children with embryonal brain tumours and correlated this with survival. More negative values of ATCT were found to be related to a lower survival probability. ATCT was shown to be a sensitive biomarker that correlated with survival in childhood embryonal brain tumours.