Heiko Schmiedeskamp1, Matus Straka1, Thomas Christen1, Jalal B. Andre2, Seema Nagpal3, Laurence Recht3, Reena P. Thomas3, Michael E. Moseley1, Greg Zaharchuk1, Roland Bammer1
1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Radiology, University of Washington, Seattle, WA, United States; 3Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States
Although multiecho sequences, such as Spin- And Gradient-Echo (SAGE) EPI, are inherently insensitive to T1-related CA extravasation effects, PWI processing can be biased by R2*- and R2-leakage effects. In this study, an approach used to correct for T1-effects was adjusted to account for R2*- and R2-related extravasation effects. The separation of ∆R2,e(*) from ∆R2,p(*) was achieved through pharmacokinetic modeling of CA passage through the brain. Hereby, a leakage constant ki was derived, facilitating improved assessment of brain tumors with DSC-PWI.