Rong Wang1, Jiaqi Ma1, Bolang Yu1, Ed X. Wu2, Jian Yang1
1Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China; 2Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China
Although brain tumor stem cells (BTSCs) are demonstrated in glioma, the origin of BTSCs remains controversial. Neural stem cells (NSCs) reside in subventricular zone (SVZ) which is the largest neurogenic region in adult brain. So SVZ is considered to be the most likely source of BTSCs. This retrospective study showed that gliomas exhibited spatial proximity to SVZ when compared to metastatic tumors, implicating and supporting the possibility that the genesis of gliomas and brain tumor stem cells may originate from the mutational NSCs in SVZ.