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Abstract #0862

Dynamic Contrast-Enhanced Quantitative Simultaneous Permeability and Perfusion Imaging of Human Brain Tumours with One-Second Temporal Resolution

Erik S. Poulsen1, Leif Ostergaard1, Patricia M. Desmond2, C Kokkinos2, Kate Drummond2, Brad Moffat2

1Center of Functionally Integrative Neuroscience (CFIN), Aarhus University Hospital, Aarhus, Denmark; 2Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia

Dynamic 3D contrast-enhanced imaging using a k-space sharing technique (TWIST) permits whole brain coverage with high special resolution at a temporal resolution of ~1 sec. Hence, simultaneous permeability and perfusion imaging of brain tumours can be acquired without the drawbacks of routinely used dynamic susceptibility contrast (DSC) technique. Permeability and perfusion measurements could serve as biomarkes of tumour grade and patient outcome. If validated, tumour vasculature pheno-typying using these biomarkers could be applied to any solid tumour. Quantitative data from ~20 brain tumour patients will be presented in comparison with DSC.