Abstract #0865

Comparisons of in vivo Physiological Imaging & Histological Characteristics for Tissue Samples from Regions of Gadolinium Enhancing & Non-Enhancing Tumor from Patients with GBM

Rupa Parvataneni¹, Ramon Barajas¹, Annette Molinaro², Gabriela Bourne¹, Emma Essock-burns¹, Joanna Phillips³, Soonmee Cha¹, Susan Chang², Sarah Nelson¹,⁴

¹Radiology and Biomedical Imaging , University of California, San Francisco, CA, United States; ²Neurosurgery, University of California, San Francisco, CA, United States; ³Pathology, University of California, San Francisco, CA, United States; ⁴Bioengineering and Therapeutic Sciences, University of California, San Francisco

The purpose of this study was to obtain image guided tissue samples from regions of suspected tumor in untreated GBM patients and compare ex vivo histopathology features with in vivo imaging biomarkers in order to characterize enhancing (CE) versus non enhancing (NE) tumor. Our study showed that DSC imaging parameters were associated with more malignant histology for CE regions, while DWI parameters were associated with more malignant histology in regions of NE tumor. These results are particularly important in delineating tumor margins during the initial surgical resection and in determining the optimal therapeutic interventions during subsequent stages of the disease.