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Abstract #0875

Probabilistic MR Atlases of Biological and Interventional Phenotypes in Human Gliomas

Benjamin M. Ellingson1, Timothy F. Cloughesy2, Whitney B. Pope1, Taryar M. Zaw1, Phioanh L. Nghiemphu2, Kourosh M. Naeini1, Robert J. Harris1, Albert Lai2

1Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States; 2Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Studies support tumor location as playing an important role in prognosis, likely due to the genetic profile of tumor precursor cells and the stage in the development cycle that these cells transform (i.e. the glioma cell of origin). However, identifying such glioma cells of origin is still a major issue challenging the field of neuro-oncology. In the current study we have constructed probabilistic atlases specifying the most frequent tumor locations on MR for more than 400 patients. These atlases were stratified by different biological and interventional phenotypes to provide new insight into niche locations of specific glioma cells of origin.