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Abstract #0885

Decreased Baseline Microvascular Volume in Acute Ischemia Induces Hemispherically Deficient Cerebrovascular Response to Hypercapnia: MRI Study Using Permanent MCAO Rat Model

Ji-Yeon Suh1, Woo Hyun Shim1, Dong-Wha Kang2, Xiaoying Wang3, Xiang Fan3, Jeong Kon Kim1, 2, Christian Farrar1, Young Ro Kim1

1Athinoula A, Martinos Center for Biomedical Imaging, Massachusettes General Hospital, Charlestown, MA, United States; 2Asan Medical Center, University of Ulsan, Seoul, Korea, Republic of; 3Neurology and Radiology, Massachusettes General Hospital, MA, United States

In this study, in order to characterize the altered vascular function in stroke brain, the relationships between the hypercanpia-induced vascular responses and the baseline vascular states are monitored using an alternating GE/SE EPI in acute permanent MCAO rats. Our results showed globally decreased cerebral responses in ipsilesional hemisphere. Interestingly, the decrease of baseline MVV in ipsilesional hemisphere was considerable, which drastic change may alter the cerebral hemodynamic properties, hence suppressing the CO2 reactivity in the entire ipsilesional hemisphere. Our results provide an important basis for understanding the impaired cerebrovascular reactivity due to occlusion of major cerebral arteries.