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Abstract #0921

Dynamic Contrast Enhanced MRI to Detect Vascular Injury in a Rat Model of Traumatic Brain Injury

Matthew D. Budde1, L. Christine Turtzo2, Eric Gold2, Lindsay Janes3, Bobbi Lewis3, Joseph A. Frank, 23

1Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States; 3Clinical Center, National Institutes of Health, Bethesda, MD, United States

We sought to investigate whether dynamic contrast enhanced (DCE) MRI could be used to monitor BBB disruption in a rat model of TBI and whether interferon beta-1b, a drug that stabilizes the blood brain barrier (BBB) and has anti-inflammatory properties, would be effective. Although the BBB was severely disrupted between 30 minutes and 7 days following injury, it did not correlate with outcome, nor did interferon beta-1b affect alter disease course. DCE effectively monitors vascular injury following TBI, but significant challenges remain in modulating the injury.