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Abstract #0946

Development of an MEMRI Biomarker for HIV-1 Infections of the Nervous System

Yutong Liu1, Aditya N. Bade2, Larisa Y. Poluektova2, Santhi Gorantla2, Howard E. Gendelman2, Michael D. Boska1

1Department of Radiology, University of Nebraska Medical Center, Omaha, NE, United States; 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States

MEMRI was performed on a mouse model of HIV-1 encephalitis generated by intracranial injection of HIV-1 infected monocyte-derived macrophages into caudate and putamen. Histological analysis showed HIV-1 infected human monocytes and gliosis about the injection sites. MEMRI showed signal enhancement in the same regions. Based on a study of neuronal and glial Mn uptake during neuroinflammation, we hypothesize that the signal enhancement results from the increased neuronal activity as a result of gliosis stimulating Mn uptake.