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Abstract #0948

Visualization of Beta-Cells in a Diabetic Mouse Model by Manganese Enhanced MRI

YauYau Wai1, 2, Jyuhn-Huarng Juang, Chia-Rui Shen, Zei-Tsan Tsai, Jiun-Jie Wang, 3, YiMing Wu

1Medical Imaging and Radiological Sciences, ChangGung University, TaoYuan, Taiwan, Taiwan; 2Chang Gung Memorial Hospital, TaoYuan, Taiwan, Taiwan; 3molecular imaging center, Chang Gung Memorial Hospital

Imaging of beta-cells provides a valuable tool for follow-up the progression of diabetes. Manganese (Mn(2+)) is a T1 contrast agent that can enter the pancreatic beta-cells through voltage-gated calcium channels. In this study, Mn(2+)- enhanced MRI after glucose infusion was acquired to detect the beta-cells in vivo. Both normal and diabetic mice were fasted and imaged. 20 minutes prior to MR acquisition, glucose was injected followed by MnCl2 administration. Pancreas was enhanced in the healthy mouse but the enhancement was reduced in the diabetic animal. Mn(2+)-enhanced MRI may allow for in vivo detection of beta-cells .