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Abstract #0950

Cornea Damage Did Not Affect Topical-Loaded Manganese-Enhanced MRI

Tiffany Thiel1, Endre Agoston1, Keelan Tuel1, Ravi Rajpoot1, Hsiao-Fang Liang1, Shu-Wei Sun1, 2

1Loma Linda University, Loma Linda, CA, United States; 2University of California, Riverside, CA, United States

Topical loaded MEMRI with 1M MnCl2 was performed biweekly for 14 weeks. Toward the end of time course, some mice appeared white eye. To evaluate the corneal and retinal integrity of these mice, Optical Coherence Imaging (OCT) and Diffusion Tensor Imaging (DTI) were used to examine animals at the end of the time course. OCT confirmed the corneal damage in the white-eye mice. Interestingly, MEMRI appeared normal in these corneal injured mice.