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Abstract #0962

Using Proteomic Analysis & MEMRI to Understand Axonal Transport Deficits and Improvements in a Mouse Model of Alzheimers Disease

Taeko Inoue1, Tabassum Majid1, 2, Robia Pautler1, 2

1Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, United States; 2Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, United States

MEMRI is an extremely useful imaging tool to demonstrate deficits in neuronal connectivity or axonal transport. We have previously used MEMRI to demonstrate axonal transport deficits in the Tg2576 mouse model of Alzheimers disease as well as improvements in Tg2576 mice that overexpress the antioxidant protein, SOD-2. To elucidate the mechanisms of these axonal transport deficits and improvements, we have combined our MEMRI data with a proteomic analysis. These data together are allowing us to understand the molecular mechanisms of the MEMRI transport deficits and improvements we have observed. Such data will allow for the development of targeted therapeutic strategies.