Abstract #0964

Neural Substrate of Morphine Withdrawal Symptoms in Rat Revealed by Manganese-Enhanced Magnetic Resonance Imaging

Haichen Niu¹, Dai Shan¹, Shaorui Li¹, Xuxia Wang¹, Fuchun Lin¹, Hao Lei¹

¹State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

Chronic morphine exposure induces dependence. Abstinence from the drug causes withdrawal symptoms. Many previous studies have investigated the neural substrate of morphine withdrawal symptoms. In this study, we employed manganese-enhanced MRI (MEMRI) technique to map accumlative brain activities in morphine-treated rat in a 24-hour period during spontaneous withdrawal.