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Abstract #0968

Optimization of the MR Acquisition Parameters for Quantitative Measurement of Brain Iron in Alzheimer's Disease

Venkata Veerendranadh Chebrolu1, Subhamoy Mandal1, Sheshadri Thiruvenkadam1, Rakesh Mullick1, John F. Schenck2

1GE Global Research, Bangalore, Karnataka, India; 2GE Global Research, Niskayuna, NY, United States

Accurate quantification of brain iron would be useful in early diagnosis of Alzheimers disease. In this work the MR acquisition parameters for quantitative measurement of brain iron (T2) were optimized through the use of Cramr-Rao bound (CRB) analysis. The noise performance at different echo-times was analyzed at different signal-to-noise ratios and at different T2. CRB analysis shows that noise performance is independent of first echo-time and there exists a line of optimality around which the optimal second echo-times for a two echo acquisition are clustered.