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Abstract #0970

Probing Age-Dependent Cerebrovascular Alterations in the Tg2576 Mouse Model of Alzheimer's Disease by Magnetic Resonance Angiography at 17.6 T

F Kara1, E S. van Dongen1, R Schliebs2, M A. van Buchem3, H J.M. de Groot1, A Alia1, 3

1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 2Department of Neurochemistry, University of Leipzig, Leipzig, Germany; 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

In this work we present the first ultra-high field (17.6 T) MR Angiography study to monitor age-dependent cerebrovascular alterations in the Tg2576 mouse model of AD. The blood flow alterations observed in middle cerebral artery and anterior communicating artery increased in transgenic mice compared to wild-type mice over time. Histological data revealed that these alterations such as signal voids might be correlated with severity of A type of cerebral amyloid angiopathy. Our results show that ultra-high field MRA is a powerful tool to monitor blood flow alterations longitudinally in living mice.