Abstract #0978

Altered Hippocampal Functional Connectivity in Patients with Mild Cognitive Impairment Who Are at Risk of Developing Alzheimer's Disease Evidence from Resting State fMRI & Cerebrospinal Fluid Biomarkers

Peter Mannfolk¹, Markus Nilsson², Sebastian Palmqvist³, Lennart Minthon³, Pia Maly Sundgren¹, Oskar Hansson³

¹Center for Medical Imaging and Physiology, Skne University Hospital, Lund, Sweden; ²Dept. of Medical Radiation Physics, Lund University, Lund, Sweden; ³Clinical Memory Research Unit, Dept. of Clinical Sciences, Lund University, Malm, Sweden

Treatment of Alzheimers disease (AD) depends upon markers to identify disease at a very early stage. Associations between cerebrospinal fluid (CSF) biomarkers and incipient AD have been established, and in this work, we investigated functional connectivity within the default mode network (DMN) in patients diagnosed with mild cognitive impairment (MCI). The patients were characterized in terms of exhibiting non-pathological or pathological CSF biomarkers, and resting state fMRI data was investigated with respect to corresponding differences in connectivity. The findings of the study indicate that connectivity of hippocampus with other nodes of the DMN is altered between the two sub groups.