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Abstract #0984

Microstructural Integrity of the Default Mode Network in Parkinsons Disease

Jeremy Goh1, 2, Tracy Melzer2, 3, Richard Watts4, Michael McAskill2, 3, Toni Pitcher2, 3, Leslie Livingston2, 3, Ross Keenan5, Tim Anderson2, 6, John Dalrymple-Alford, 12

1Department of Psychology, University of Canterbury, Christchurch, Canterbury, New Zealand; 2New Zealand Brain Research Institute, Christchurch, Canterbury, New Zealand; 3Department of Medicine, University of Otago, Dunedin, New Zealand; 4College of Medicine, University of Vermont, Burlington, VT, United States; 5Christchurch Radiology Group, Christchurch, Canterbury, New Zealand; 6Department of Neurology, Christchurch Hospital, Christchurch, Canterbury, New Zealand

The Default Mode Network (DMN) is evaluated in three groups of patients with Parkinson's Disease (PD) and one group of healthy controls (HC). The three groups are patients with PD without a diagnosis of neurological disorders (PD-N), patients with mild cognitive impairment (PD-MCI), and patients with a diagnosis of dementia (PD-D). The MD values across the DMN differed significantly across the four groups (F(3,122) = 6.26, p<0.001), with significant post-hoc Newman-Keuls differences between the PD-D group and all other groups, and significant differences between the PD-MCI group and both PD-N and the HC groups, which did not differ.