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Abstract #0994

Impaired Glutamatergic & GABAergic Function at Early Age in APPswe-PS1dE9 Mice: Implications for Preclinical Diagnosis of Alzheimers Disease

Vivek Tiwari1, Anant Bahadur Patel1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

APP-PS1 mice show occasional deposits of amyloid plaques at the age of 5-6 months without significant memory impairment and neuronal loss, characteristics typical of AD pathology at early stage of the disease. Present study evaluates glutamatergic and GABAergic neurotransmitter energetics in 6 month old APPswe-PS1dE9 by using 1H-[13C]-NMR spectroscopy together with infusion of [1,6-13C2]glucose. Although APPswe-PS1dE9 mice at 6 month age exhibited no significant derangement in neurochemical profile but glucose oxidation and neurotransmitter flux associated with glutamatergic and GABAergic neurons were found to be significantly impaired.