Impaired Glutamatergic & GABAergic Function at Early Age in APPswe-PS1dE9 Mice: Implications for Preclinical Diagnosis of Alzheimers Disease

Vivek Tiwari¹, Anant Bahadur Patel¹

APP-PS1 mice show occasional deposits of amyloid plaques at the age of 5-6 months without significant memory impairment and neuronal loss, characteristics typical of AD pathology at early stage of the disease. Present study evaluates glutamatergic and GABAergic neurotransmitter energetics in 6 month old APPswe-PS1dE9 by using ¹H-[¹³C]-NMR spectroscopy together with infusion of [1,6-¹³C₂]glucose. Although APPswe-PS1dE9 mice at 6 month age exhibited no significant derangement in neurochemical profile but glucose oxidation and neurotransmitter flux associated with glutamatergic and GABAergic neurons were found to be significantly impaired.