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Abstract #1008

To Investigate the Cerebral Vasomotor Reactivity by CO2 Stimulus Using Cine PCMRI

Chun-Jung Juan1, Yi-Jui Liu2, Yi-Hsiung Lee3, Teng-Yi Huang4, Fu-Nien Wang5, Ming-Long Wu6

1Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan; 2Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan; 3P.H.D program in Electrical and Communication Engineering, Feng Chia University, Taichung, Taiwan; 4Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 5Department of Biomedical Engineering and Environmental Sciences College of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan; 6Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan

The blood flow waveforms of one cardiac cycle were recorded using cine PCMRI in different hypercapnia condition (0~7% CO2). Vasomotor reactivity (VMR) is an increased percentage change of cerebral perfusion for hypercapnia to normocapnia. Four types of VMR were defined in this study, VMRsys-flow, VMRmean-flow, VMRdia-flow and VMRstr-volume computed by systolic blood flow, mean blood flow, diastolic blood flow and stroke volume, respectively. Although the physiological interpretation of VMR is different between blood volume and flow, our result demonstrated the VMRstr-volume is closer to VMRmean-flow under different CO2 induced hypercapnia comparing with other two blood flow VMR indexes.