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Abstract #1022

Restoring Cerebro-Vascular Reserve in Carotid Artery Disease

Kay Jann1, Manuela Wapp2, Patrik Michel3, Marwan El-Koussy2, Frauke Kellner-Weldon2, Martinus Hauf2, Gerhard Schroth2, Andrea Federspiel1

1Dept. of Psychiatric Neurophysiology, University Hospital of Psychiatry / University of Bern, Bern, Switzerland; 2Institute for Diagnostic and Interventional Neuroradiology, Inselspital / Bern University Hospital, Bern, Switzerland; 3Dept. of Neurology, University Hospital Lausanne, Lausanne, Switzerland

In carotid artery disease (CAD) information about cerebral blood flow assessed by pCASL identified brain areas with reduced cerebro-vascular reserve capacity (CVR) due to the occlusion of a feeding vessel. A reduction of CVR was associated to cognitive deficits in CAD. In this study we investigated whether revascularization therapy restores CVR in the affected vascular flow territories in a 12 month follow up. Our results indicate the ability of revascularisation therapy to restore CVR in patients with CAD. Specifically, the CVR of the anterior watershed area was markedly increased after intervention