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Abstract #1030

Evaluation of a Multiparametric Quantitative BOLD Approach to Map Local Blood Oxygen Saturation in Stroke Patients

Julien Bouvier1, 2, Marjorie Villien1, 3, Sylvie Grand, 34, Assia Jaillard, 45, Olivier Detante, 14, David Chechin2, Jean-Francois Le Bas4, 5, Alexandre Krainik, 14, Emmanuel L. Barbier1, 3, Irene Tropres5

1Grenoble Institute of Neurosciences, Grenoble, France; 2Philips Healthcare, Suresnes, France; 3INSERM U836, Grenoble, France; 4CHU Grenoble, Grenoble, France; 53T Facility, SFR Biomedical NMR and Neurosciences, Grenoble, France

Local oxygen saturation maps (lSO2) may be obtained using separate estimates of T2, T2*, blood volume fraction (BVf), and B0 inhomogeneities. In this study, we collected lSO2 and perfusion maps (BVf and CBF) in seven stroke patients six weeks after stroke. CBF is higher in the contralateral area than in its periphery and in the non-necrotic pixels of the lesion, while BVf values are comparable between these three regions. The reduced lSO2 in the lesion is consistent with the lower CBF observed in this area and may be the sign of a glial inflammatory scar.