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Abstract #1033

Availability for Brain Ischemic Lesions Validation from Diffusion Weighed Image Difference between Single-Refocused & Twice-Refocused Spin-Echo Sequence

Kazuhiro Nakamura1, Takumi Takahashi2, Yasushi Kondoh1, Guoyue Chen2, Toshibumi Kinoshita1

1Akita Research Institute for Brain and Blood Vessels, Akita, Japan; 2Akita Prefectural University, Ugohonjo, Akita, Japan

Diffusion weighted imaging with typical single refocused pulsed-gradient spin-echo (SRSE-DWI) sequence is interacted by susceptibility-induced background gradient fields around vessels, while the effect is reduced in twice-refocused spin-echo (TRSE-DWI) sequence. The difference between SRSE-DWI and TRSE-DWI will indicate CBV weighted image. We evaluated the ADC reduced ratio in both sequence with Monte-Carlo simulations in a vascular model. The results indicate effective criteria for brain stroke validation from diffusion weighed image of twice-refocused spin-echo sequence.