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Abstract #1070

Three-Dimensional Volumetric Analysis of Substantia Nigra in Parkinsons Disease at 7.0T MRI

Hye Jin Jeong1, Se Hong Oh1, Jong Min Kim2, Dae Hyuk Kown1, Sung Yeon Park1, Young Bo Kim1, Beom S Jeon2, Zang Hee Cho1

1Neuroscience Research Instiute, Gachon University of Medicine and Science, Incheon, Korea, Republic of; 2College of Medicine, Department of Neurology, Seoul National University, Seoul, Korea, Republic of

Parkinsons disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN).Especially the degree of neuronal loss was significantly higher in the nigrosomes. We were directly investigated volume changes in the SN between the normal controls and PD patients by using 7.0T MRI. In the intermediate and caudal aspects, significant correlation was found subgroups of nigrosomes. The measured correlation analyses show that UPDRS motor score dependent correlation. Change of the SN structure has been regarded to hold greatest potential for use in the diagnosis of PD.