Topological Changes of the Brain Functional Network During Performance of Self-Initiated Movement in PD Patients

Xiaojun Xu¹, Dan Long², Minming Zhang²

Patients with Parkinson's disease (PD) have difficulty in performing self-initiated movements. Although the relationship between the dysfunction of SMA and the defect of self-initiated movements in PD patients has been well established, little has been known about how the dysfunction of SMA affected the whole functional network during movement. In this study, using fMRI and complex network analysis based on graph theory, we demonstrated the topological changes of the brain networks during performance of self-initiated movement in PD patients.