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Abstract #1092

Comprehensive Analysis of Brain Metabolites in the CST of ALS Patients

Varan Govind1, Khema Sharma2, Andrew A. Maudsley1, Kristopher L. Arheart3, Gaurav Saigal1, Sulaiman Sheriff1

1Radiology, University of Miami, Miami, FL, United States; 2Neurology, University of Miami; 3Epidemiology and Public Health, University of Miami

In previous studies, proton MR-observed brain metabolite data analysis in the primary motor cortex and corticospinal tract was performed using manually drawn regions-of-interest (ROIs). Such an approach is bound to have subjectivity introduced by the manual selection of ROIs. In this study, a comprehensive analysis of brain metabolite [N-acetyl aspartate (NAA), total-creatine (Cre) and total-choline (Cho)] alterations in the CST of subjects with ALS was performed using a 3D CST atlas.