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Abstract #1100

Optimization of T1 Measurement Using Mixed Flip Angle and TR

Yu Sub Sung1, Seonjoo Kwon1, Woo Hyun Shim1, Gyunggoo Cho2, Hyungjoon Cho3, Jeong Kon Kim, 14, Bruce Rosen1, Young Ro Kim1

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States; 2Korea Basic Science Institute; 3Ulsan National Institute of Science and Technology; 4Asan Medical Center, University of Ulsan

Accurate determination of T1 values in the brain is clinically important for assessing various neurological diseases and also for the successful execution of perfusion and dynamic contrast agent studies. In this work, we propose a clinically practical T1measurement method using the widely available 3D gradient echo sequence and the optimized acquisition strategy with mixed FA and TR for efficiently and accurately calculating T1 maps in the brain. This new combination method is an attractive alternative to other conventional methods, providing accurate T1 measurements in a reasonable scan time.