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Abstract #1108

Correlations Between Ex-Vivo MRI and Hippocampal Sub-Field Neuronal Density in Temporal Lobe Epilepsy

Maged Goubran1, 2, Terry M. Peters1, 3, Ali R. Khan4

1Robarts Research Institute , London, Ontario, Canada; 2Biomedical Engineering, University of Western Ontario, London , Ontario, Canada; 3Biomedical Engineering, University of Western Ontario, London, Ontario, Canada; 4Robarts Research Institute, London, Ontario, Canada

The identification of cellular abnormalities in histology of the resected tissue has the potential to validate the effectiveness of multi-spectral magnetic resonance imaging (MRI) in pre-operative foci localization in temporal lobe epilepsy. We investigated the correlation between ex-vivo MR images and neuronal cell density of hippocampal sub-fields from histological slides. Segmented cell counts of hippocampal sub-fields were consistent with pathological findings as well as local entropy values of MR images. We have shown that ex-vivo MR images have the potential to differentiate between the hippocampal sub-fields through local features and entropy measurements.